The goal of the NIH Microphysiological Systems program is to develop bio-engineered microdevices that represent functional units of the 10 major human organ systems: circulatory, respiratory, integumentary, reproductive, endocrine, gastrointestinal, nervous, urinary, musculoskeletal, and immune using hiPSCs. This unique and novel in vitro platform could help ensure that safe and effective therapeutics are identified sooner, and ineffective or toxic ones are rejected early in the drug development process. These microfabricated devices are also useful for modeling human diseases and may prove to be sufficient alternatives to the use of animal models.
Dr. Danilo Tagle is Associate Director for Special Initiatives at the National Center for Advancing Translational Sciences (NCATS). He leads and manages the 1) NIH Microphysiological Systems program, 2) Extracellular RNA Communication program, and 3) the Stimulating Peripheral Activity to Relive Conditions (SPARC) program. These multidisciplinary programs involve coordination of activities with other NIH institutes and centers, including the NIH Common Fund, as well as partnerships with other government agencies, such FDA and DARPA, and the private sector. In addition to being Associate Director for Special Initiatives, Dr. Tagle recently served as Acting Director for the NCATS Office of Grants Management and Scientific Review, and currently serves as Executive Secretary to the NCATS Advisory Council, as well as the Cures as well as the Cures Acceleration Network Review Board.