【BIO-2】 Influence of Enteric Environment on Immunity - From Resident Bacteria to Radiation -

May 12[Thu]
Chairman: Hiroshi Kiyono
Director and Professor,
International Research and Development Center for Mucosal Vaccines,
The Institute of Medical Science,
The University of Tokyo

Acute and Chronic Radiation Injury in Small Intestine

Satoshi Uematsu
Dept. of Mucosal Immunology,
School of Medicine, Chiba University/
Project Professor, Div. of Innate immune regulation, International Research and Development Center for Mucosal Vaccine, Institute of Medical Science, The University of Tokyo

High-dose ionizing radiation damages DNA and induces various disorders according to the radiation sensitivity of each organ. Gastrointestinal tract is one of radio-sensitive organs. I will show the roles of innate immunity in acute and chronic radiation injury.

Gut Commensal Microbiota and the Gut Immune System

Hiroshi Ohno
Group Director,
Center for Integrative Medical Sciences, RIKEN

Inside our gut colonized an enormous number of commensal bacteria, collectively called "gut microbiota", which closely interacts with us host and profoundly affects our health and disease state. The gut immune system somehow senses gut microbiota to contain them. By contrast, gut microbiota stimulates and promotes the development of gut immune system.

After graduating School of Medicine, Chiba University in 1983 and spending 4 years in clinical medicine (Anesthesiology), I entered Graduate School of Medicine, Chiba University where trained in Immunology, and graduated in 1991 (Ph.D.) After working as an Research Associate (during which spending 3 year at NIH as a postdoc to learn cell biology) and an Associate Professor at the Chiba University, moved to Kanazawa University as a full Professor in 1999. I joined RIKEN Research Center for Allergy and Immunology as a Team Leader in 2004, and became a Group Director at the RIKEN Center for Integrative Medical Sciences in 2013. Visiting professorship at the Yokohama City University and Chiba University. Working on Intestinal Immunology and host-gut microbiota interaction.